REJURAN Ⅰ

Rejuran I is a polynucleotide (PN)-based skin rejuvenation injectable specifically formulated for delicate and thin skin areas, especially around the eyes. It is designed to improve skin quality, reduce signs of aging such as fine lines, dark circles, and loss of elasticity, and restore a smoother, healthier under-eye appearance.

Indication

Rejuran I is commonly used for:

• Fine lines and wrinkles around the eyes (crow’s feet, under-eye lines)

• Dark circles and uneven skin tone in the peri-orbital area

• Thin, fragile under-eye skin

• Loss of elasticity and early signs of aging

• Mild under-eye hollowness and skin crepiness

• Skin hydration and barrier repair in sensitive areas

Origin

Rejuran I originates from South Korea and is part of the Rejuran skin rejuvenation line developed for regenerative aesthetic treatments. It is widely used in dermatology and aesthetic medicine for biorevitalization and skin healing support.

Composition

• Main active ingredient: Polynucleotides (PN), specifically sodium polynucleotide

• Derived from purified salmon DNA fragments

• Biocompatible with human tissue and designed for high safety and low immunogenic reaction risk

• Formulated in a lighter, more fluid consistency than other Rejuran variants to suit delicate eye-area injections

Mechanism of Action

Rejuran I works through biological skin regeneration rather than volumizing:

• Stimulates fibroblast activity, increasing collagen and elastin production

• Enhances skin repair and tissue regeneration

• Improves microcirculation and skin barrier function

• Supports hydration retention in the dermis

• Reduces inflammation and promotes recovery of damaged skin structures

Benefits

Regular treatment may help achieve:

• Reduction of fine lines and wrinkles around the eyes

• Improved skin elasticity and firmness

• Brighter and more even under-eye tone

• Reduction in appearance of dark circles

• Enhanced hydration and smoother skin texture

• Overall youthful and refreshed eye appearance

Treatment Protocol

• Initial phase: 3 to 4 sessions

• Interval: every 2 to 4 weeks between sessions

• Maintenance: every 3 to 6 months depending on skin condition and clinical evaluation

• Visible improvement typically begins after the first few sessions, with progressive results over time

Administration

• Injection technique: intradermal injection or cannula method

• Needle size: ultra-fine (commonly 34G, ~4mm)

• Applied after topical numbing cream to minimize discomfort

• Target area: peri-orbital region (under-eyes and crow’s feet area)

Safety Profile

Rejuran I is generally well tolerated when administered by trained professionals:

• Mild and temporary side effects may include redness, swelling, or small injection bumps

• These effects typically resolve within hours to a few days

• Minimal downtime is expected

• Low risk of allergic reaction due to high biocompatibility of PN

Combination Therapies

Rejuran I can be combined with other aesthetic treatments such as:

• Energy-based devices (e.g., HIFU) for skin tightening

• Laser treatments for texture and pigmentation improvement

• Microneedling or resurfacing procedures for enhanced collagen stimulation

Combination therapy may improve overall results and support faster skin recovery after procedures.

Packaging

• 1 syringe per box

• 1 mL per syringe

• Single-use sterile medical product

• For professional use only

Important Note

Rejuran I is a professional injectable treatment intended for use by qualified medical practitioners trained in aesthetic procedures.