A precision-formulated injectable, ONE TOX® leverages Clostridium botulinum toxin type A to smooth moderate-to-severe dynamic wrinkles and relieve targeted muscle hyperactivity.
Product Profile
- Active Ingredient: 100 U Clostridium botulinum toxin type A per vial
- Excipients: Human serum albumin (0.5 mg), sodium chloride (0.9 mg)
- Presentation: Lyophilized white-to-light yellow powder in a clear vial
- Reconstitution: Add sterile, preservative-free 0.9 % saline; swirl gently; use within 24 hours
- Storage: Refrigerate at 2–8 °C; do not freeze
Mechanism of Action
ONE TOX® temporarily blocks acetylcholine release at neuromuscular junctions, producing localized muscle relaxation. In aesthetic treatments, this softens expression lines; in therapeutic settings, it reduces muscle spasms.
Indications
Aesthetic Uses
- Glabellar (frown) lines
- Forehead wrinkles
- Crow’s feet
- Perioral lines
- Masseter contouring
- Eyebrow lifting
- Platysmal band smoothing
Therapeutic Uses
- Hyperhidrosis (excessive sweating)
- Bruxism (teeth grinding)
- Muscle spasticity (e.g., cerebral palsy)
- Blepharospasm
- Off-label: chronic migraine relief
Dosing & Administration
-
Reconstitution Ratios:
- 1 mL saline → 100 U/mL
- 2 mL saline → 50 U/mL
- Injection: Administer intramuscularly according to clinical guidelines, adjusting dose by treatment area.
- Onset: 2–5 days
- Duration: 4–6 months (varies by individual and site)
Safety & Precautions
- Administer only by trained professionals.
- Common reactions: injection-site pain, swelling, bruising, headache, transient ptosis or localized weakness.
- Rare but serious: dysphagia, respiratory compromise—monitor high-risk patients.
Shelf Life
Three years from manufacture. Maintain continuous cold-chain refrigeration to preserve potency.
