NABOTA 200U

NABOTA® 200 Units is a highly purified botulinum toxin type A product used for both aesthetic and therapeutic treatments. Manufactured using advanced purification technology, it temporarily relaxes targeted muscles to reduce the appearance of dynamic facial wrinkles and manage various neuromuscular conditions. NABOTA is recognized internationally for its high purity, consistent efficacy, and safety profile.

Origin

• Manufacturer: Daewoong Pharmaceutical

• Country of Origin: South Korea

• Product Type: Botulinum Toxin Type A for aesthetic and medical applications

Composition

Each vial contains:

• Clostridium botulinum toxin type A – 200 Units

• Human serum albumin – 0.5 mg

• Sodium chloride – 0.9 mg

Mechanism of Action

NABOTA works by blocking the release of acetylcholine at the neuromuscular junction. This temporary interruption of nerve signaling reduces muscle contractions, resulting in smoother skin appearance and relief from conditions associated with excessive muscle activity.

Indications

Aesthetic Indications

NABOTA is commonly used for the temporary improvement of:

• Moderate to severe glabellar lines (frown lines between the eyebrows)

• Forehead lines

• Lateral canthal lines (crow's feet)

• Perioral wrinkles

• Other dynamic facial wrinkles caused by repetitive muscle movement

Therapeutic Indications

Botulinum toxin type A may be used by qualified healthcare professionals for:

• Chronic migraine management

• Cervical dystonia and muscle spasticity

• Axillary hyperhidrosis (excessive underarm sweating)

• Neurogenic detrusor overactivity and urinary incontinence

• Other neuromuscular disorders as determined by a physician

Appearance and Reconstitution

• Presented as a sterile, vacuum-dried (lyophilized) powder.

• Appearance ranges from white to pale yellow.

• Reconstitute with sterile, preservative-free 0.9% sodium chloride solution according to the desired concentration.

• For a concentration of 4 Units per 0.1 mL, add 5 mL of diluent to a 200 U vial.

• Gently rotate the vial during reconstitution; avoid vigorous shaking.

Administration

• Administered via intramuscular injection.

• Injection technique, dosage, and treatment areas should be determined according to the patient's anatomy and treatment objectives.

• Treatments are typically repeated every 3–6 months, depending on individual response and clinical indication.

Expected Results

• Initial effects may begin to appear within 2–7 days after treatment.

• Maximum improvement is typically observed within 1–2 weeks.

• Results generally last between 3 and 6 months, depending on the treatment area and individual metabolism.

Storage

• Store unopened vials at 2°C–8°C.

• Do not freeze.

• Protect from excessive heat and direct sunlight.

• Reconstituted solution should be handled aseptically and used according to established clinical guidelines.

Shelf Life

• Up to 36 months when stored under recommended conditions.

Safety Information

• Intended for administration by qualified healthcare professionals experienced in botulinum toxin procedures.

• Do not use in patients with known hypersensitivity to botulinum toxin type A or any component of the formulation.

• Use caution in patients with neuromuscular disorders or active infection at the injection site.

• Patients should be evaluated thoroughly before treatment.

Possible Side Effects

Common adverse reactions may include:

• Injection-site pain or redness

• Mild swelling or bruising

• Headache

• Temporary muscle weakness

• Eyelid drooping (ptosis)

• Localized discomfort

Most side effects are mild and temporary. Patients should seek medical attention if unusual or severe symptoms occur.

Packaging

• 1 vial containing 200 Units of Botulinum Toxin Type A (lyophilized powder) for reconstitution prior to use.

Key Benefits

• High-purity botulinum toxin formulation

• Consistent and predictable clinical performance

• Suitable for both aesthetic and therapeutic applications

• Long-lasting results with minimal downtime

• Manufactured according to stringent quality and safety standards

NABOTA® 200 Units is widely utilized in aesthetic medicine and therapeutic neurology for its effectiveness in reducing muscle activity and improving the appearance of dynamic wrinkles while maintaining a natural-looking outcome.