NABOTA 100U

NABOTA® is a highly purified botulinum toxin type A injectable treatment developed for both aesthetic and therapeutic applications. Manufactured using advanced purification technology, it temporarily relaxes targeted muscles by inhibiting nerve signals responsible for muscle contraction. This helps reduce the appearance of dynamic facial wrinkles and manage several medical conditions associated with excessive muscle activity.

NABOTA® is produced by Daewoong Pharmaceutical and is widely used by healthcare professionals worldwide for facial rejuvenation and therapeutic treatments.

Origin

• Brand: NABOTA®

• Manufacturer: Daewoong Pharmaceutical

• Country of Origin: South Korea

• Product Type: Botulinum Toxin Type A Injectable

• Packaging: 1 vial containing 100 Units of Botulinum Toxin Type A

Composition

Each vial contains:

• Botulinum Toxin Type A – 100 Units

• Human Serum Albumin

• Sodium Chloride

The product is supplied as a sterile, vacuum-dried (lyophilized) powder that must be reconstituted with preservative-free 0.9% sodium chloride solution before administration.

Mechanism of Action

NABOTA® works by blocking the release of acetylcholine at the neuromuscular junction. This temporarily interrupts communication between nerves and muscles, resulting in localized muscle relaxation. The reduction in muscle activity helps smooth expression lines and wrinkles while also providing therapeutic benefits in conditions involving muscle overactivity or excessive sweating.

Indications

Aesthetic Indications

NABOTA® is commonly used to improve:

• Glabellar lines (frown lines between the eyebrows)

• Horizontal forehead lines

• Crow's feet around the eyes

• Bunny lines on the nose

• Perioral wrinkles

• Chin dimpling

• Brow asymmetry and brow lifting procedures

• Neck bands (platysmal bands)

Therapeutic Indications

NABOTA® may be used for:

• Chronic migraine prevention

• Cervical dystonia

• Blepharospasm

• Muscle spasticity

• Hemifacial spasm

• Axillary hyperhidrosis (excessive underarm sweating)

• Palmar and plantar hyperhidrosis (excessive sweating of palms and soles)

• Certain bladder disorders associated with muscle overactivity

Key Benefits

• Smooths moderate to severe dynamic facial wrinkles

• Creates a more youthful and refreshed appearance

• Helps prevent deepening of expression lines

• Reduces excessive sweating in targeted areas

• Provides relief from certain muscle spasm disorders

• Offers clinically proven and predictable results

• Minimal downtime after treatment

• Long-lasting effects with regular maintenance

Reconstitution and Dilution

NABOTA® should be reconstituted using sterile, preservative-free 0.9% saline.

Common Dilution Guide

The appropriate dilution depends on the treatment area and clinical objective.

Administration

• Administered via intramuscular or intradermal injection.

• A 30–33 gauge needle is typically recommended.

• Treatment should only be performed by licensed and trained healthcare professionals.

• Injection points and dosage should be individualized according to patient anatomy and treatment goals.

Typical Dosage

• Cosmetic Treatments: Generally 20–60 Units per session.

• Therapeutic Treatments: Higher doses may be required depending on the condition being treated.

Treatment Interval

• Most patients undergo treatment every 3–6 months.

• Typically 2–4 treatment sessions per year are sufficient to maintain results.

Duration of Results

• Initial effects may become noticeable within 2–7 days after treatment.

• Full results are generally visible within 1–2 weeks.

• Cosmetic effects commonly last between 3–6 months, though duration may vary depending on individual factors and treatment area.

Storage

• Store unopened vials at 2°C–8°C.

• Do not freeze.

• Protect from excessive heat and direct sunlight.

• Follow aseptic handling procedures during reconstitution and administration.

Shelf Life

• Up to 36 months from the date of manufacture when stored under recommended conditions.

Safety Information

Common Side Effects

• Mild pain at the injection site

• Redness or swelling

• Bruising

• Headache

• Temporary muscle weakness near the treatment area

Contraindications

NABOTA® should not be used in patients with:

• Known hypersensitivity to botulinum toxin or formulation components

• Active infection at the proposed injection site

• Certain neuromuscular disorders, such as myasthenia gravis or Lambert-Eaton syndrome

Professional Use

NABOTA® is a prescription medical product intended for administration by qualified healthcare professionals. Proper patient assessment, dosing, and injection technique are essential to ensure safe and effective outcomes.