LIPORASE

Liporase is a sterile, injectable enzyme preparation containing hyaluronidase, used in aesthetic and medical practice to break down hyaluronic acid (HA). It is primarily employed to correct or reverse results of HA-based dermal fillers when outcomes are overcorrected, uneven, misplaced, or associated with complications.

Hyaluronidase is a naturally occurring enzyme that depolymerizes hyaluronic acid by hydrolyzing its molecular bonds, allowing for gradual dissolution of filler material in treated tissues.

Composition

• Active ingredient: Hyaluronidase enzyme

• Form: Lyophilized (freeze-dried) sterile powder

• Typical strength: 1500 IU per vial (varies by manufacturer batch specifications)

Mechanism of Action

Hyaluronidase works by breaking down hyaluronic acid into smaller fragments, reducing its viscosity and accelerating its dispersion and absorption in tissues. In aesthetic medicine, this allows for targeted reduction or complete reversal of HA dermal fillers.

Indications

Liporase is used under qualified medical supervision for:

• Correction of excessive or uneven hyaluronic acid filler placement

• Reversal of unsatisfactory cosmetic filler results

• Management of vascular compromise caused by accidental intravascular filler injection (medical emergency use in clinical settings)

• Treatment of localized overcorrection or nodules related to HA fillers

• Facilitating diffusion of other injectable substances in specific medical contexts (adjunct use)

Presentation

• Typically supplied as a box containing 10 sterile vials

• Each vial contains freeze-dried hyaluronidase powder intended for reconstitution prior to use

• Single-use sterile glass ampoules

Preparation & Administration

• The powder is reconstituted with sterile normal saline or appropriate diluent under clinical conditions

• Administration is performed via injection into the affected tissue area

• Use is strictly limited to trained healthcare professionals due to the risk of overcorrection and tissue sensitivity

Onset & Duration

• Initial enzymatic activity begins shortly after administration

• Visible clinical effect may develop within hours, with full results typically observed within 12–24 hours, depending on tissue response and amount of filler present

Storage Conditions

• Unopened vials: Store refrigerated at 2°C to 8°C

• Do not freeze

• Protect from direct light and heat

• Reconstituted solution: may be stored short-term under controlled temperature conditions as per clinical protocol, but generally recommended for immediate use to ensure potency

Possible Side Effects

Common transient effects may include:

• Mild redness at injection site

• Swelling or localized tenderness

• Itching or irritation

• Temporary discomfort in treated area

Rare but serious reactions may include:

• Allergic reactions (including hypersensitivity)

• Swelling of lips, tongue, or throat

• Respiratory difficulty

• Visual disturbances (if near orbital region)

• Systemic reactions such as fever or cardiovascular irregularities

Contraindications & Precautions

Hyaluronidase should be used with caution or avoided in:

• Known hypersensitivity to hyaluronidase or formulation components

• Active infection at injection site

• Pregnancy and breastfeeding (use only under strict medical evaluation)

• Non-indicated use such as routine edema reduction from insect bites or unrelated swelling conditions